Insm 1 cooperates with Neurod 1 and Foxa 2 to maintain mature pancreatic b-cell function

@inproceedings{Jia2015Insm1C,
  title={Insm 1 cooperates with Neurod 1 and Foxa 2 to maintain mature pancreatic b-cell function},
  author={Shiqi Jia and Andranik Ivanov and Dinko Blasevic and Thomas Mueller and Bettina Purf{\"u}rst and Wei Sun and Wei Chen and Matthew N Poy and Nikolaus Rajewsky and Carmen Birchmeier},
  year={2015}
}
Key transcription factors control the gene expression program in mature pancreatic b-cells, but their integration into regulatory networks is little understood. Here, we show that Insm1, Neurod1 and Foxa2 directly interact and together bind regulatory sequences in the genome of mature pancreatic b-cells. We used Insm1 ablation in mature b-cells in mice and found pronounced deficits in insulin secretion and gene expression. Insm1-dependent genes identified previously in developing b-cells… CONTINUE READING

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