Insilico studies of 2-methylheptyl isonicotinate produced by Streptomyces sps. 201 against dihydrodipicolinate synthase enzyme of Mycobacterium tuberculosis

@article{Singh2012InsilicoSO,
  title={Insilico studies of 2-methylheptyl isonicotinate produced by Streptomyces sps. 201 against dihydrodipicolinate synthase enzyme of Mycobacterium tuberculosis},
  author={S. P. Singh and R. Bezbaruah and T. Bora},
  journal={Journal of Biophysical Chemistry},
  year={2012},
  volume={3},
  pages={233-237}
}
Tuberculosis is thought to have infected one-third of the world’s population and antibiotic resistance is a growing problem in multi-drug-resistant tuberculosis which is caused by Mycobacterium tuberculosis (MTB). It has been reported that Mycobacterial cell walls are characterized by high DAP (diaminopimelic acid) content—an intermediate of the (S)-lysine biosynthetic pathway. Hence, the Lysine/DAP biosynthetic pathway is a promising target because of its role in cell wall and amino acid… Expand
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SHOWING 1-10 OF 33 REFERENCES
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Conformationally constrained diketopimelic acid analogues as inhibitors of dihydrodipicolinate synthase.
Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive.
Isolation and Structure Elucidation of a New Antifungal and Antibacterial Antibiotic Produced by Streptomyces sp. 201
MolDock: a new technique for high-accuracy molecular docking.
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