Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2

@inproceedings{Li2015InsightsOS,
  title={Insights on Structural Characteristics and Ligand Binding Mechanisms of CDK2},
  author={Yan Li and Jingxiao Zhang and Weimin Gao and Lilei Zhang and Yanqiu Pan and Shuwei Zhang and Yonghua Wang and Bing Yan},
  booktitle={International journal of molecular sciences},
  year={2015}
}
Cyclin-dependent kinase 2 (CDK2) is a crucial regulator of the eukaryotic cell cycle. However it is well established that monomeric CDK2 lacks regulatory activity, which needs to be aroused by its positive regulators, cyclins E and A, or be phosphorylated on the catalytic segment. Interestingly, these activation steps bring some dynamic changes on the 3D-structure of the kinase, especially the activation segment. Until now, in the monomeric CDK2 structure, three binding sites have been reported… CONTINUE READING
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