Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids

@inproceedings{Presman2010InsightsOG,
  title={Insights on Glucocorticoid Receptor Activity Modulation through the Binding of Rigid Steroids},
  author={Diego Mart{\'i}n Presman and Lautaro Dami{\'a}n {\'A}lvarez and Valeria Levi and Silvina L Eduardo and Michelle A Digman and Marcelo A. Marti and Adriana S. Veleiro and Gerardo Burton and Adal{\'i} Pecci},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The glucocorticoid receptor (GR) is a transcription factor that regulates gene expression in a ligand-dependent fashion. This modular protein is one of the major pharmacological targets due to its involvement in both cause and treatment of many human diseases. Intense efforts have been made to get information about the molecular basis of GR activity. METHODOLOGY/PRINCIPAL FINDINGS Here, the behavior of four GR-ligand complexes with different glucocorticoid and antiglucocorticoid… CONTINUE READING