Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues.

Abstract

Glycogen synthase kinase 3beta (GSK 3beta) is a key component of several cellular processes including Wnt and insulin signalling pathways. The interaction of GSK3beta with scaffolding peptide axin is thought to be responsible for the effective phosphorylation of beta-catenin, the core effector of Wnt signaling, which has been linked with the occurrence of… (More)

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@article{Zhang2007InsightsIU, title={Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3beta-axin complex: role of packing hydrophobic residues.}, author={Na Zhang and Yongjun Jiang and Jianwei Zou and Shulin Zhuang and Haixiao Jin and Qingsen Yu}, journal={Proteins}, year={2007}, volume={67 4}, pages={941-9} }