Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis.

@article{Lall2016InsightsIT,
  title={Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis.},
  author={Namrita Lall and Elizabeth Mogapi and Marco Nuno de Canha and Bridget G. Crampton and Mabatho Nqephe and Ahmed A. Hussein and Vivek Kumar},
  journal={Bioorganic \& medicinal chemistry},
  year={2016},
  volume={24 22},
  pages={
          5953-5959
        }
}
Greyia radlkoferi ethanol extract and its five compounds were tested for their inhibitory activity against the mushroom tyrosinase enzyme and melanin production on melanocytes. The crude extract showed significant tyrosinase inhibition with IC50 of 17.96μg/ml. This is the first report of the isolation of these 5 compounds from Greyia radlkoferi. 2',4',6'-Trihydroxydihydrochalcone showed the highest tyrosinase inhibition at 17.70μg/ml (68.48μM), with low toxicity when compared with crude extract… Expand
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