Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation.

@article{Chirgadze1998InsightsIT,
  title={Insights into the structure of hepatocyte growth factor/scatter factor (HGF/SF) and implications for receptor activation.},
  author={Dimitri Y. Chirgadze and Jonathan Hepple and Richard Byrd and R. Sowdhamini and Tom L. Blundell and Ermanno Gherardi},
  journal={FEBS letters},
  year={1998},
  volume={430 1-2},
  pages={126-9}
}
The modular structure of HGF/SF offers a reductionist or 'divide and rule' approach to the analysis of structure and function. Domain deletion experiments have established that the N domain, kringle 1 and kringle 2 are essential for HGF/SF activity and that truncated variants containing the N domain and kringle 1 (NK1) or kringles 1 and 2 (NK2) can exhibit partial agonistic or antagonistic activity depending on target cells. Comparative modelling has been used to predict the 3D structures of… CONTINUE READING

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