Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies.

@article{Sharom1999InsightsIT,
  title={Insights into the structure and substrate interactions of the P-glycoprotein multidrug transporter from spectroscopic studies.},
  author={Frances Jane Sharom and Ronghua Liu and Y Romsicki and Peihua Lu},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1461 2},
  pages={327-45}
}
The P-glycoprotein multidrug transporter is a 170-kDa efflux pump which exports a diverse group of natural products, chemotherapeutic drugs, and hydrophobic peptides across the plasma membrane, driven by ATP hydrolysis. The transporter has been proposed to interact with its drug substrates within the membrane environment; however, much remains to be learned about the nature and number of the drug binding site(s). The two nucleotide binding domains are responsible for ATP binding and hydrolysis… CONTINUE READING

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