Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis

@article{Padhi2019InsightsIT,
  title={Insights into the role of ribonuclease 4 polymorphisms in amyotrophic lateral sclerosis},
  author={Aditya K. Padhi and Priyam Narain and Upma Dave and Rohit Satija and Anirudh Patir and James Gomes},
  journal={Journal of Biomolecular Structure and Dynamics},
  year={2019},
  volume={37},
  pages={116 - 130}
}
Mutations in certain genes of the Ribonuclease (RNASE) superfamily can cause amyotrophic lateral sclerosis (ALS) through altered RNA processing mechanisms. About 30 of these missense mutations in RNASE5/ANG gene have already been reported in ALS patients. In another gene of the ribonuclease superfamily, ribonuclease 4 (RNASE4), missense mutations and single nucleotide polymorphisms have been identified in patients suffering from ALS. However, their plausible molecular mechanisms of association… Expand
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