Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells.

@article{Yu2013InsightsIT,
  title={Insights into the role of focal adhesion modulation in myogenic differentiation of human mesenchymal stem cells.},
  author={Haiyang Yu and Yuan Siang Lui and Sijing Xiong and Wen Shing Leong and Feng Wen and Himawan Nurkahfianto and Sravendra Rana and David Tai Leong and Kee Woei Ng and Lay Poh Tan},
  journal={Stem cells and development},
  year={2013},
  volume={22 1},
  pages={136-47}
}
We report the establishment of a novel platform to induce myogenic differentiation of human mesenchymal stem cells (hMSCs) via focal adhesion (FA) modulation, giving insights into the role of FA on stem cell differentiation. Micropatterning of collagen type I on a polyacrylamide gel with a stiffness of 10.2 kPa efficiently modulated elongated FA. This elongated FA profile preferentially recruited the β(3) integrin cluster and induced specific myogenic differentiation at both transcription and… CONTINUE READING