Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry

@article{Pagano2009InsightsIT,
  title={Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry},
  author={Mario Pagano and Michael A. Clynes and Nanako Masada and Antonio Ciruela and Laura-Jo Ayling and Sebastian Wachten and Dermot M F Cooper},
  journal={American Journal of Physiology - Cell Physiology},
  year={2009},
  volume={296},
  pages={C607 - C619}
}
Adenylyl cyclases (ACs) are a family of critically important signaling molecules that are regulated by multiple pathways. Adenylyl cyclase 8 (AC8) is a Ca(2+) stimulated isoform that displays a selective regulation by capacitative Ca(2+) entry (CCE), the process whereby the entry of Ca(2+) into cells is triggered by the emptying of intracellular stores. This selectivity was believed to be achieved through the localization of AC8 in lipid raft microdomains, along with components of the CCE… CONTINUE READING

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