Insights into the regulation of the MXR response in haemocytes of the Mediterranean mussel (Mytilus galloprovincialis).

@article{Franzellitti2016InsightsIT,
  title={Insights into the regulation of the MXR response in haemocytes of the Mediterranean mussel (Mytilus galloprovincialis).},
  author={Silvia Franzellitti and Teresa Striano and Paola Valbonesi and Elena Fabbri},
  journal={Fish & shellfish immunology},
  year={2016},
  volume={58},
  pages={
          349-358
        }
}
This study investigated functional and transcriptional modulation of the Multixenobiotic resistance (MXR) system as a cytoprotective mechanism contributing to the physiological chemoresistance of haemocytes in the Mediterranean mussel. Basal transport activity was assessed using the model substrate rhodamine 123 and specific inhibitors for the MXR-related transporters P-glycoprotein (ABCB mRNA) and Multidrug resistance-related protein (ABCC mRNA). Results showed that MXR activity in mussel… CONTINUE READING
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