Insights into the pathophysiology and therapy of myeloproliferative neoplasms from mouse models

@inproceedings{Etten2014InsightsIT,
  title={Insights into the pathophysiology and therapy of myeloproliferative neoplasms from mouse models},
  author={Richard A. Van Etten},
  year={2014}
}
CML (chronic myeloid leukemia) is genetically simple cancer, having a very few point mutations or copy number variations in its early chronic phase genome. Therapies using ABL1 tyrosine kinase inhibitors (TKIs) have dramatically altered the prognosis in CML. The major goal of current molecular research on CML is to understand TKI resistance and disease progression. CML mouse models can provide information and insights into the pathophysiology of this disease that are difficult or impossible to… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 23 REFERENCES

Stat5a/b are essential for normal lymphoid development and differentiation.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2006