Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.

@article{Ward2016InsightsIT,
  title={Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility.},
  author={Marc A. Ward and Joseph Francis Pierre and Raquel Franco Leal and Yong Huang and Benjamin D Shogan and Sushila R. Dalal and Christopher R. Weber and Vanessa Leone and Mark W Musch and Gary An and Mrinalini Chatta Rao and David T Rubin and Laura E. Raffals and Dionysios A. Antonopoulos and Mitch L Sogin and Neil H. Hyman and John C Alverdy and Eugene B Chang},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2016},
  volume={310 11},
  pages={
          G973-88
        }
}
Gut dysbiosis, host genetics, and environmental triggers are implicated as causative factors in inflammatory bowel disease (IBD), yet mechanistic insights are lacking. Longitudinal analysis of ulcerative colitis (UC) patients following total colectomy with ileal anal anastomosis (IPAA) where >50% develop pouchitis offers a unique setting to examine cause vs. effect. To recapitulate human IPAA, we employed a mouse model of surgically created blind self-filling (SFL) and self-emptying (SEL) ileal… CONTINUE READING