Insights into the origin of high activity and stability of catalysts derived from bulky, electron-rich monophosphinobiaryl ligands in the Pd-catalyzed C-N bond formation.

@article{Strieter2003InsightsIT,
  title={Insights into the origin of high activity and stability of catalysts derived from bulky, electron-rich monophosphinobiaryl ligands in the Pd-catalyzed C-N bond formation.},
  author={Eric R Strieter and Donna G Blackmond and Stephen L Buchwald},
  journal={Journal of the American Chemical Society},
  year={2003},
  volume={125 46},
  pages={13978-80}
}
A comparative kinetic examination of catalyst systems based on several monophosphinobiaryl ligands is reported. The bulk of the phosphine ligand controls the catalytic activity and the rate of catalyst activation with the catalyst based on 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl providing the greatest activity and fastest activation. In the… CONTINUE READING