Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.

@article{Leask2004InsightsIT,
  title={Insights into the molecular mechanism of chronic fibrosis: the role of connective tissue growth factor in scleroderma.},
  author={Andrew Leask and Christopher P. Denton and David J. Abraham},
  journal={The Journal of investigative dermatology},
  year={2004},
  volume={122 1},
  pages={1-6}
}
Connective tissue growth factor (CCN2), a member of the CCN family of proteins, is a cysteine-rich matricellular protein. Connective tissue growth factor is not normally expressed in dermal fibroblasts unless induced. The most potent inducer of connective tissue growth factor thus far identified is transforming growth factor beta. Connective tissue growth factor, however, is constitutively overexpressed by fibroblasts present in skin fibrotic lesions, including scleroderma. The overexpression… CONTINUE READING

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