Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

@article{Levites2006InsightsIT,
  title={Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.},
  author={Yona R Levites and Lisa A. Smithson and Robert W. Price and Rachel S. Dakin and Bin Yuan and Michael Sierks and Jungsu Kim and Eileen McGowan and Dana Kim Reed and Terrone L. Rosenberry and Pritam Das and Todd E Golde},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2006},
  volume={20 14},
  pages={2576-8}
}
A number of hypotheses regarding how anti-Abeta antibodies alter amyloid deposition have been postulated, yet there is no consensus as to how Abeta immunotherapy works. We have examined the in vivo binding properties, pharmacokinetics, brain penetrance, and alterations in Abeta levels after a single peripheral dose of anti-Abeta antibodies to both wild-type (WT) and young non-Abeta depositing APP and BRI-Abeta42 mice. The rapid rise in plasma Abeta observed after antibody (Ab) administration is… CONTINUE READING