Insights into the mechanism of activation of the phosphorylation-independent response regulator NblR. Role of residues Cys69 and Cys96.

@article{Espinosa2012InsightsIT,
  title={Insights into the mechanism of activation of the phosphorylation-independent response regulator NblR. Role of residues Cys69 and Cys96.},
  author={Javier Espinosa and Maria-Luisa L{\'o}pez-Redondo and Laura Miguel-Romero and Jos{\'e} L Neira and Alberto Marina and Asunci{\'o}n Contreras},
  journal={Biochimica et biophysica acta},
  year={2012},
  volume={1819 5},
  pages={382-90}
}
Cyanobacteria respond to environmental stress conditions by adjusting their photosynthesis machinery. In Synechococcus sp. PCC 7942, phycobilisome degradation and other acclimation responses after nutrient or high light stress require activation by the phosphorylation-independent response regulator NblR. Structural modelling of its receiver domain suggested a role for Cys69 and Cys96 on activation of NblR. Here, we investigate this hypothesis by engineering Cys to Ala substitutions. In vivo and… CONTINUE READING

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