Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis.

@article{Wang2015InsightsIT,
  title={Insights into the mechanism of CXCL12-mediated signaling in trophoblast functions and placental angiogenesis.},
  author={Liang Wang and Xueyi Li and Yilin Zhao and Chao Fang and Yingli Lian and Wenli Gou and Tao Han and Xiao-Ming Zhu},
  journal={Acta biochimica et biophysica Sinica},
  year={2015},
  volume={47 9},
  pages={663-72}
}
The chemokine CXCL12 and its receptor CXCR4 are important signaling components required for human blastocyst implantation and the progression of pregnancy. Growing evidence indicates that the CXCL12/CXCR4 axis can regulate trophoblast function and uterine spiral artery remodeling, which plays a fundamental role in placentation and fetal outcome. The orphan receptor CXCR7 is also believed to partly regulate the function of the CXCL12/CXCR4 axis. Additionally, the CXCL12/CXCR4/CXCR7 axis can… CONTINUE READING
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