Insights into the function of a sperm-surface progesterone receptor: evidence of ligand-induced receptor aggregation and the implication of proteolysis.

@article{Tesarik1993InsightsIT,
  title={Insights into the function of a sperm-surface progesterone receptor: evidence of ligand-induced receptor aggregation and the implication of proteolysis.},
  author={Jan Tesarik and Carmen Concepci{\'o}n Jimenez Mendoza},
  journal={Experimental cell research},
  year={1993},
  volume={205 1},
  pages={111-7}
}
Human spermatozoa have recently been introduced as a model for the study of rapid, nongenomic effects of steroids on the cell. Indirect evidence suggests the presence of a novel type of progesterone receptor on the cell surface; some cellular responses mediated by the receptor have been shown to be sensitive to protease inhibitors, but the molecular identity and the mode of function of this receptor are not known. Recent biochemical evidence showed that Ca2+ influx and a Ca(2+)-dependent… CONTINUE READING