Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.

@article{Vali2008InsightsIT,
  title={Insights into the effects of alpha-synuclein expression and proteasome inhibition on glutathione metabolism through a dynamic in silico model of Parkinson's disease: validation by cell culture data.},
  author={Shireen Vali and Shankar J Chinta and Jun Peng and Zeba Sultana and Neetu Singh and Purushottam Sharma and S. Sharada and Julie K Andersen and Muchukunte Mukunda Srinivas Bharath},
  journal={Free radical biology & medicine},
  year={2008},
  volume={45 9},
  pages={
          1290-301
        }
}
Dopaminergic neurodegeneration during Parkinson disease (PD) involves several pathways including proteasome inhibition, alpha-synuclein (alpha-syn) aggregation, mitochondrial dysfunction, and glutathione (GSH) depletion. We have utilized a systems biology approach and built a dynamic model to understand and link the various events related to PD pathophysiology. We have corroborated the modeling data by examining the effects of alpha-syn expression in the absence and presence of proteasome… CONTINUE READING

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