Insights into the biochemistry of the ubiquitous NhaP family of cation/H+ antiporters.

  title={Insights into the biochemistry of the ubiquitous NhaP family of cation/H+ antiporters.},
  author={Craig T. Resch and Judith L. Winogrodzki and Claudia C. H{\"a}se and Pavel Dibrov},
  journal={Biochemistry and cell biology = Biochimie et biologie cellulaire},
  volume={89 2},
Na+/H+ antiporters are integral membrane proteins that exchange Na+ for H+ across the cytoplasmic or organellar membranes of virtually all living cells. They are essential for control of cellular pH, volume homeostasis, and regulation of Na+ levels. Na+/H+ antiporters have become increasingly characterized and are now becoming important drug targets. The recently identified NhaP family of Na+/H+ antiporters, from the CPA1 superfamily, contains proteins with a surprisingly broad collective range… CONTINUE READING


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Ion binding and selectivity of the rotor ring of the Na+-transporting V-ATPase.

Proceedings of the National Academy of Sciences of the United States of America • 2008

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