Insights into the ageing mind: a view from cognitive neuroscience

  title={Insights into the ageing mind: a view from cognitive neuroscience},
  author={Trey Hedden and John D. E. Gabrieli},
  journal={Nature Reviews Neuroscience},
As we grow older, we may grow wiser, but we can also experience memory loss and cognitive slowing that can interfere with our daily routines. The cognitive neuroscience of human ageing, which relies largely on neuroimaging techniques, relates these cognitive changes to their neural substrates, including structural and functional changes in the prefrontal cortex, medial temporal lobe regions and white matter tracts. Much remains unknown about how normal ageing affects the neural basis of… 

Ageing, cognition, and neuroscience: An introduction

The main goal of this special issue is to report new cognitive data in normal and pathological ageing that are related to neural data at different levels, and to summarise briefly the large variety of topics dealt with in the articles.

Neurobiology of cognitive aging: Insights from imaging genetics

White Matter and Cognitive Decline in Aging: A Focus on Processing Speed and Variability

This review considers methodological advances with particular relevance to the role of WM in age-related changes in processing speed and emphasizes that the combined implementation of intra-individual variability and neuroimaging techniques hold promise for specifying the WM-processing speed relationship with implications for normative and clinical samples.

Impact of aging brain circuits on cognition

There is remarkable consistency in the pattern of age‐related neural and cognitive change observed in healthy humans and other animals, including changes in cognitive operations that are known to be dependent on the hippocampus, as well as those requiring intact prefrontal cortical circuits.

Age-related changes in prefrontal cortex function: links between sleep EEG and cognition

Healthy ageing has been found to be accompanied by changes in slow wave activity (SWA) and cognitive function. Furthermore, these changes have been seen predominantly in the prefrontal cortex (PFC)

Dissociating Normal Aging from Alzheimer’s Disease: A View from Cognitive Neuroscience

  • M. Toepper
  • Psychology, Biology
    Journal of Alzheimer's disease : JAD
  • 2017
Qualitative differences in neurocognitive changes associated with normal aging and Alzheimer’s disease clearly indicate that AD cannot be simply described as accelerated aging process but on the contrary represents a solid entity.

Brain structure and cognitive ability in healthy aging: a review on longitudinal correlated change

The present article reviews the current longitudinal evidence on correlated changes between magnetic resonance imaging-derived measures of brain structure and laboratory-based measures of fluid cognitive ability in healthy older adults and provides guidance for future researchers by presenting ideas to stimulate theory and methods for development.



New visions of the aging mind and brain

Hemispheric asymmetry reduction in older adults: the HAROLD model.

The HAROLD model is a cognitive neuroscience model that integrates ideas and findings from psychology and neuroscience of aging that is supported by functional neuroimaging and other evidence in the domains of episodic memory, semantic memory, working memory, perception, and inhibitory control.

Individual differences in the cognitive and neurobiological consequences of normal aging

Neuroanatomical correlates of cognitive aging: evidence from structural magnetic resonance imaging.

The results indicate that shrinkage of the prefrontal cortex mediates age-related increases in perseveration, and the volume of visual processing areas predicted performance on nonverbal working memory tasks.

Age-related memory decline: current concepts and future directions.

  • S. Small
  • Psychology
    Archives of neurology
  • 2001
Questions about the effect of age on memory and the brain, and attempts at early answers are discussed, are reviewed herein.

The neurobiology of memory changes in normal aging

An application of prefrontal cortex function theory to cognitive aging.

  • R. West
  • Psychology, Biology
    Psychological bulletin
  • 1996
The frontal lobe hypothesis of cognitive aging is found to perform well, with the exception of an inability to account for age-related declines in item recall and recognition memory, possibly a result of age- related declines in medial temporal function.

Ageing, fitness and neurocognitive function

It is found that those who received aerobic training showed substantial improvements in performance on tasks requiring executive control compared with anaerobically trained subjects.

Morphometry of the human cortex cerebri and corpus striatum during aging

Life span and synapses: will there be a primary senile dementia?