Insights into the Role of Follicular Helper T Cells in Autoimmunity

  title={Insights into the Role of Follicular Helper T Cells in Autoimmunity},
  author={Hong-Jai Park and Do-Hyun Kim and Sang-Ho Lim and Won-Ju Kim and Jeehee Youn and Youn-Soo Choi and J L Choi},
  booktitle={Immune network},
Follicular helper T (TFH) cells are recently highlighted as their crucial role for humoral immunity to infection as well as their abnormal control to induce autoimmune disease. During an infection, naïve T cells are differentiating into TFH cells which mediate memory B cells and long-lived plasma cells in germinal center (GC). TFH cells are characterized by their expression of master regulator, Bcl-6, and chemokine receptor, CXCR5, which are essential for the migration of T cells into the B… CONTINUE READING


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