Insights into the Pathogenesis of Pancreatic Cystic Neoplasms

  title={Insights into the Pathogenesis of Pancreatic Cystic Neoplasms},
  author={Vrishketan Sethi and Bhuwan Giri and Ashok Saluja and Vikas Dudeja},
  journal={Digestive Diseases and Sciences},
With the current epidemic of diagnosed pancreatic cystic neoplasms on the rise, a substantial amount of work has been done to unravel their biology, thus leading to implications on clinical decision making. Recent genetic profiling of resected human specimens has identified alterations in signaling pathways involving KRAS and GNAS signaling as early events in the pathogenesis of intraductal pancreatic mucinous neoplasms. Progressively, mutations in genes such as TP53, SMAD4, RNF43, and others… CONTINUE READING