Insights into the Packing Switching of the EphA2 Transmembrane Domain by Molecular Dynamic Simulations.

Abstract

Receptor tyrosine kinases play an important role in mediating cell migration and adhesion associated with various biology processes. With a single-span transmembrane domain (TMD), the activities of the receptors are regulated by the definite packing configurations of the TMDs. For the EphA2 receptor, increasing studies have been conducted to investigate the… (More)
DOI: 10.1021/acs.jpcb.5b01116

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