Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?

@article{Brenner2003InsightsIT,
  title={Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?},
  author={Catherine Brenner and Morgane Le Bras and Guido Kroemer},
  journal={Journal of Clinical Immunology},
  year={2003},
  volume={23},
  pages={73-80}
}
Mitochondria are potent integrators/coordinators of apoptosis signaling pathways. Indeed, under physiological conditions, the initiation of apoptosis leads to the accumulation of second messengers that converge on mitochondria. In response, these organelles undergo a membrane permeabilization, presumably due to the opening of protein channels, culminating… CONTINUE READING