Insights into the GTPase Mechanism of EF-Tu from Structural Studies

@inproceedings{Hilgenfeld2000InsightsIT,
  title={Insights into the GTPase Mechanism of EF-Tu from Structural Studies},
  author={Rolf Hilgenfeld and Jeroen R Mesters and Tanis Hogg},
  year={2000}
}
The main role of EF-Tu is clearly in the elongation phase of bacterial protein synthesis. The protein transports aminoacylated tRNA (aa-tRNA) molecules to the programmed ribosome and profoundly contributes to an accurate and fast translation of mRNAs into proteins. EF-Tu was the first protein found to be regulated by the binding and subsequent hydrolysis of GTP, making it a paradigm for the superfamily of regulatory GTPases. The rather loose structure of the GDP complex, originally seen with an… CONTINUE READING