Insights into the Evolution of Longevity from the Bowhead Whale Genome

@inproceedings{Keane2015InsightsIT,
  title={Insights into the Evolution of Longevity from the Bowhead Whale Genome},
  author={Michael G. Keane and Jeremy R. Semeiks and Andrew E. Webb and Yang I. Li and V{\'i}ctor Quesada and Thomas Craig and Lone B. Madsen and Sipko van Dam and David Brawand and Patr{\'i}cia Isabel Ferreira Marques and Pawel Michalak and Lin Kang and Jong Bhak and Hyung-Soon Yim and Nick V. Grishin and Nynne Hjort Nielsen and Mads Peter Heide-J{\o}rgensen and Elias M Oziolor and Cole W Matson and George M Church and Gary W. Stuart and John C. Patton and Joseph C George and Robert Scott Suydam and K. Lindorff Larsen and Carlos L{\'o}pez-Ot{\'i}n and Mary J. O’Connell and John W. Bickham and Bo Thomsen and Jo{\~a}o Pedro de Magalh{\~a}es},
  booktitle={Cell reports},
  year={2015}
}
The bowhead whale (Balaena mysticetus) is estimated to live over 200 years and is possibly the longest-living mammal. These animals should possess protective molecular adaptations relevant to age-related diseases, particularly cancer. Here, we report the sequencing and comparative analysis of the bowhead whale genome and two transcriptomes from different populations. Our analysis identifies genes under positive selection and bowhead-specific mutations in genes linked to cancer and aging. In… CONTINUE READING
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Human Ageing

  • R. Tacutu, T. Craig, +6 authors J. P. de Magalhães
  • 2013
Highly Influential
5 Excerpts

A note on biological data from the hunt of bowhead whales in West Greenland 2009-2011

  • M. P. Heide-Jørgensen, E. Garde, N. H. Nielsen, O. N. Andersen, S. H. Hansen
  • J. Cetacean Res. Manag
  • 2012
Highly Influential
3 Excerpts

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