Insights into the Conformational Variability and Regulation of Human Nek2 Kinase

@inproceedings{Westwood2009InsightsIT,
  title={Insights into the Conformational Variability and Regulation of Human Nek2 Kinase},
  author={Isaac M. Westwood and Donna-Marie Cheary and Joanne E. Baxter and Mark W Richards and Rob L. M. van Montfort and Andrew M Fry and Richard Bayliss},
  booktitle={Journal of molecular biology},
  year={2009}
}
The Nek family of serine/threonine kinases regulates centrosome and cilia function; in addition, several of its members are potential targets for drug discovery. Nek2 is dimeric, is cell cycle regulated and functions in the separation of centrosomes at G2/M. Here, we report the crystal structures of wild-type human Nek2 kinase domain bound to ADP at 1.55-A resolution and T175A mutant in apo form as well as that bound to a non-hydrolyzable ATP analog. These show that regions of the Nek2… CONTINUE READING

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