Insights into the Biosynthetic Origin of 3-(3-Furyl)alanine in Stachylidium sp. 293 K04 Tetrapeptides.

@article{Maddah2016InsightsIT,
  title={Insights into the Biosynthetic Origin of 3-(3-Furyl)alanine in Stachylidium sp. 293 K04 Tetrapeptides.},
  author={Fayrouz El Maddah and S. Kehraus and M. Nazir and C. Almeida and G. K{\"o}nig},
  journal={Journal of natural products},
  year={2016},
  volume={79 11},
  pages={
          2838-2845
        }
}
  • Fayrouz El Maddah, S. Kehraus, +2 authors G. König
  • Published 2016
  • Biology, Medicine
  • Journal of natural products
  • The marine-sponge-derived fungus Stachylidium sp. 293 K04 produces the N-methylated peptides endolide A (1) and endolide B (2), showing affinity for the vasopressin receptor 1A and serotonin receptor 5HT2B, respectively. Both peptides feature the rare amino acid 3-(3-furyl)alanine. Isotope labeling experiments, employing several 13C-enriched precursors, revealed that this unprecedented heterocyclic amino acid moiety in endolide A (1) is synthesized from a cyclic intermediate of the shikimate… CONTINUE READING
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