Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8

@article{Maier2014InsightsIT,
  title={Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8},
  author={Sarah Maier and T. Pfl{\"u}ger and S. Loesgen and Katharina Asmus and E. Br{\"o}tz and T. Paululat and A. Zeeck and S. Andrade and Andreas Bechthold},
  journal={ChemBioChem},
  year={2014},
  volume={15}
}
  • Sarah Maier, T. Pflüger, +6 authors Andreas Bechthold
  • Published 2014
  • Biology, Medicine
  • ChemBioChem
  • Mensacarcin, a potential antitumour drug, is produced by Streptomyces bottropensis. The structure consists of a three‐membered ring system with many oxygen atoms. Of vital importance in this context is an epoxy moiety in the side chain of mensacarcin. Our studies with different mensacarcin derivatives have demonstrated that this epoxy group is primarily responsible for the cytotoxic effect of mensacarcin. In order to obtain further information about this epoxy moiety, inactivation experiments… CONTINUE READING
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