Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8

@article{Maier2014InsightsIT,
  title={Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8},
  author={Sarah Maier and T. Pfl{\"u}ger and S. Loesgen and Katharina Asmus and E. Br{\"o}tz and T. Paululat and A. Zeeck and S. Andrade and Andreas Bechthold},
  journal={ChemBioChem},
  year={2014},
  volume={15}
}
  • Sarah Maier, T. Pflüger, +6 authors Andreas Bechthold
  • Published 2014
  • Biology, Medicine
  • ChemBioChem
    • Mensacarcin, a potential antitumour drug, is produced by Streptomyces bottropensis. The structure consists of a three‐membered ring system with many oxygen atoms. Of vital importance in this context is an epoxy moiety in the side chain of mensacarcin. Our studies with different mensacarcin derivatives have demonstrated that this epoxy group is primarily responsible for the cytotoxic effect of mensacarcin. In order to obtain further information about this epoxy moiety, inactivation experiments… CONTINUE READING
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    9 Citations
    Background Citations
    4
    9 Citations
    Citation Type

    Citation Type

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    Diversity and evolution of bacterial bioluminescence genes in the global ocean
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    References

    SHOWING 1-10 OF 52 REFERENCES
    Enzymatic chemistry of cyclopropane, epoxide, and aziridine biosynthesis.
    • 131
    The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol.
    • 113
    Cloning and Heterologous Expression of Three Type II PKS Gene Clusters from Streptomyces bottropensis
    • 19
    Identification and characterization of gerPI and gerPII involved in epoxidation and hydroxylation of dihydrochalcolactone in Streptomyces species KCTC 0041BP
    • 4
    Towards a total synthesis of the new anticancer agent mensacarcin: synthesis of the carbocyclic core.
    • 21
    Epoxyquinone Formation Catalyzed by a Two‐Component Flavin‐Dependent Monooxygenase Involved in Biosynthesis of the Antibiotic Actinorhodin
    • 14
    Enzymatic processing of fumiquinazoline F: a tandem oxidative-acylation strategy for the generation of multicyclic scaffolds in fungal indole alkaloid biosynthesis.
    • 63
    Purification and characterization of recombinant squalene epoxidase.
    • 48
    • PDF
    Synthesis of Highly Functionalized Anthraquinones and Evaluation of Their Antitumor Activity
    • 35
    Crystal structure of methylenetetrahydromethanopterin reductase (Mer) in complex with coenzyme F420: Architecture of the F420/FMN binding site of enzymes within the nonprolyl cis‐peptide containing bacterial luciferase family
    • 49