Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8

  title={Insights into the Bioactivity of Mensacarcin and Epoxide Formation by MsnO8},
  author={Sarah Maier and T. Pfl{\"u}ger and S. Loesgen and Katharina Asmus and E. Br{\"o}tz and T. Paululat and A. Zeeck and S. Andrade and Andreas Bechthold},
  • Sarah Maier, T. Pflüger, +6 authors Andreas Bechthold
  • Published 2014
  • Biology, Medicine
  • ChemBioChem
  • Mensacarcin, a potential antitumour drug, is produced by Streptomyces bottropensis. The structure consists of a three‐membered ring system with many oxygen atoms. Of vital importance in this context is an epoxy moiety in the side chain of mensacarcin. Our studies with different mensacarcin derivatives have demonstrated that this epoxy group is primarily responsible for the cytotoxic effect of mensacarcin. In order to obtain further information about this epoxy moiety, inactivation experiments… CONTINUE READING
    9 Citations
    New Insights into the Biosynthesis Pathway of Polyketide Alkaloid Argimycins P in Streptomyces argillaceus
    • 8
    • PDF
    Isolation and structural characterization of a non-diketopiperazine phytotoxin from a potato pathogenic Streptomyces strain
    • 3
    The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells
    • 17
    • PDF
    A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137
    • 3
    Formation of an Angular Aromatic Polyketide from a Linear Anthrene Precursor via Oxidative Rearrangement.
    • 7
    • PDF
    Bioenergetics underlying single cell migration on aligned nanofiber scaffolds.
    • 2


    The structure of U17 isolated from Streptomyces clavuligerus and its properties as an antioxidant thiol.
    • 113
    Cloning and Heterologous Expression of Three Type II PKS Gene Clusters from Streptomyces bottropensis
    • 19
    Purification and characterization of recombinant squalene epoxidase.
    • 48
    • PDF