Insights into signaling from the beta2-adrenergic receptor structure.

  title={Insights into signaling from the beta2-adrenergic receptor structure.},
  author={Martin Audet and Michel Bouvier},
  journal={Nature chemical biology},
  volume={4 7},
With more than 800 members, the G protein-coupled receptor family constitutes the largest group of membrane proteins involved in signal transduction. Until the end of last year, high-resolution three-dimensional structures were available for only one of them--the light receptor rhodopsin. Recently the structure of the beta(2)-adrenergic receptor has been obtained, and it revealed interesting differences with the structure of rhodopsin. Analyses of these differences raise important questions… CONTINUE READING

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