Insights into quinaldic acid moiety formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation.

@article{Duan2012InsightsIQ,
  title={Insights into quinaldic acid moiety formation in thiostrepton biosynthesis facilitating fluorinated thiopeptide generation.},
  author={Lian Duan and Shoufeng Wang and Rijing Liao and Wen Liu},
  journal={Chemistry & biology},
  year={2012},
  volume={19 4},
  pages={443-8}
}
Thiostrepton (TSR), often referred as to a parent compound in the thiopeptide family, is a bimacrocyclic member that features a quinaldic acid (QA) moiety-containing side ring appended to the characteristic core system. QA biosynthesis requires an unusual ring-expanding conversion, showing a methyl transfer onto and a rearrangement of the indole part of L-tryptophan to give a quinoline ketone. Herein, we report that the process involves the activities of the radical methyltransferase TsrT… CONTINUE READING

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