Insights into pneumococcal pathogenesis from the crystal structure of the modular teichoic acid phosphorylcholine esterase Pce

@article{Hermoso2005InsightsIP,
  title={Insights into pneumococcal pathogenesis from the crystal structure of the modular teichoic acid phosphorylcholine esterase Pce},
  author={Juan A Hermoso and Laura Lagartera and Ana Carolina Gonzalez and Meike Stelter and Pedro de Moura Garcia and Mart{\'i}n Mart{\'i}nez-Ripoll and J{\'e}ssica Leite Garcia and Margarita Men{\'e}ndez},
  journal={Nature Structural &Molecular Biology},
  year={2005},
  volume={12},
  pages={533-538}
}
Phosphorylcholine, a specific component of the pneumococcal cell wall, is crucial in pathogenesis. It directly binds to the human platelet-activating factor (PAF) receptor and acts as a docking station for the family of surface-located choline-binding proteins (CBP). The first structure of a complete pneumococcal CBP, Pce (or CbpE), has been solved in complex with the reaction product and choline analogs. Pce has a novel modular structure, with a globular N-terminal module containing a… CONTINUE READING
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References

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Showing 1-10 of 59 references

Crystallization and preliminary X-ray diffraction studies of the pneumococcal teichoic acid phosphorylcholine esterase Pce

  • L Lagartera
  • Acta Crystallogr. F
  • 2005

Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae

  • R Luo
  • EMBO J. 24,
  • 2005

Cell wall hydrolases

  • R. López, E. García, P. García, J. L. García
  • B.G.) 75–
  • 2004

Choline-binding proteins. In The Pneumococcus

  • E. Swiatlo, L. S. McDaniel, D. E. Briles
  • 2004

Structural basis for selective recognition of pneumococcal cell wall by modular endolysin from phage Cp-1

  • Hermoso, J.A
  • Structure 11,
  • 2003

a critical update

  • M. B. Pepys, Hirschfield, G. M. C-reactive protein
  • J. Clin. Invest. 111, 1805–1812
  • 2003

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