Insights into ototoxicity. Analogies to nephrotoxicity.

  • H David Humes
  • Published 1999 in Annals of the New York Academy of Sciences


The most common ototoxic compounds in clinical practice are aminoglycoside antibiotics, cisplatin, and loop diuretics (ethacrynic acid and furosemide). These agents also have substantial renal effects in the form of nephrotoxicity or diuresis. The understanding of these renal effects may provide insight into ototoxic mechanisms. For aminoglycosides, the… (More)


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