Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction.

@article{Grammatopoulos2012InsightsIM,
  title={Insights into mechanisms of corticotropin-releasing hormone receptor signal transduction.},
  author={Dimitris Grammatopoulos},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 1},
  pages={
          85-97
        }
}
During evolution, mammals have developed remarkably similar molecular mechanisms to respond to external challenges and maintain survival. Critical regulators of these mechanisms are the family of 'stress'-peptides that consists of the corticotropin-releasing hormone (CRH) and urocortins (Ucns). These neuropeptides 'fine-tune' integration of an intricate series of physiological responses involving the autonomic, endocrine, immune, cardiovascular and reproductive systems, which induce a spectrum… CONTINUE READING
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