Insights into interphase large-scale chromatin structure from analysis of engineered chromosome regions.


How chromatin folds into mitotic and interphase chromosomes has remained a difficult question for many years. We have used three generations of engineered chromosome regions as a means of visualizing specific chromosome regions in live cells and cells fixed under conditions that preserve large-scale chromatin structure. Our results confirm the existence of… (More)
DOI: 10.1101/sqb.2010.75.050


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