Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies.

@article{Bonelli2006InsightsII,
  title={Insights into in vivo activities of lantibiotics from gallidermin and epidermin mode-of-action studies.},
  author={Raquel R Bonelli and Tanja Schneider and H. -G. Sahl and Imke Wiedemann},
  journal={Antimicrobial agents and chemotherapy},
  year={2006},
  volume={50 4},
  pages={1449-57}
}
The activity of lanthionine-containing peptide antibiotics (lantibiotics) is based on different killing mechanisms which may be combined in one molecule. The prototype lantibiotic nisin inhibits peptidoglycan synthesis and forms pores through specific interaction with the cell wall precursor lipid II. Gallidermin and epidermin possess the same putative lipid II binding motif as nisin; however, both peptides are considerably shorter (22 amino acids, compared to 34 in nisin). We demonstrate that… CONTINUE READING

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