Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells.

@article{Klener2006InsightsIG,
  title={Insights into gene expression changes impacting B-cell transformation: cross-species microarray analysis of bovine leukemia virus tax-responsive genes in ovine B cells.},
  author={Pavel Klener and Maud Szynal and Yvette Cleuter and Makram Merimi and Hugues Duvillier and Françoise Lallemand and Claude Bagnis and Philip Griebel and Christos Sotiriou and Ars{\`e}ne Burny and Philippe Martiat and Anne Van den Broeke},
  journal={Journal of virology},
  year={2006},
  volume={80 4},
  pages={1922-38}
}
Large-animal models for leukemia have the potential to aid in the understanding of networks that contribute to oncogenesis. Infection of cattle and sheep with bovine leukemia virus (BLV), a complex retrovirus related to human T-cell leukemia virus type 1 (HTLV-1), is associated with the development of B-cell leukemia. Whereas the natural disease in cattle is characterized by a low tumor incidence, experimental infection of sheep leads to overt leukemia in the majority of infected animals… CONTINUE READING

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