Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.

@article{Huang2007InsightsIF,
  title={Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.},
  author={Lei Huang and Jin-na Min and Shane C. Masters and Nahid F Mivechi and Demetrius Moskophidis},
  journal={Genesis},
  year={2007},
  volume={45 8},
  pages={487-501}
}
The mammalian small heat shock protein (sHSPs) family is comprised of 10 members and includes HSPB1, which is proposed to play an essential role in cellular physiology, acting as a molecular chaperone to regulate diverse cellular processes. Whilst differential roles for sHSPs are suggested for specific tissues, the relative contribution of individual sHSP family members in cellular and organ physiology remains unclear. To address the function of HSPB1 in vivo and determine its tissue-specific… CONTINUE READING

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