Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.

@article{Kontopidis2003InsightsIC,
  title={Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.},
  author={George Kontopidis and Martin J I Andrews and Campbell McInnes and A. Keith. Cowan and Helen Powers and Lorraine Innes and Andy Plater and Gary Griffiths and Dougie Paterson and Daniella I Zheleva and D. P. Lane and Stephen M Green and Malcolm D. Walkinshaw and Peter M. Fischer},
  journal={Structure},
  year={2003},
  volume={11 12},
  pages={1537-46}
}
Inhibition of CDK2/CA (cyclin-dependent kinase 2/cyclin A complex) activity through blocking of the substrate recognition site in the cyclin A subunit has been demonstrated to be an effective method for inducing apoptosis in tumor cells. We have used the cyclin binding motif (CBM) present in the tumor suppressor proteins p21(WAF1) and p27(KIP1) as a template to optimize the minimal sequence necessary for CDK2/CA inhibition. A series of peptides were prepared, containing nonnatural amino acids… CONTINUE READING