Tissue-specific transcription of the neuronal gene Lim3 affects Drosophila melanogaster lifespan and locomotion
Locomotor deficits frequently accompany aging in animals. These deficits are often caused by degeneration in the nervous and musculoskeletal systems. Insects are an excellent model for age-related behavior studies because they are short-lived and have a reduced nervous system with fewer cells than vertebrates. Furthermore, they are highly mobile and display a complex set of locomotor behaviors. This review presents research that has examined age-related locomotor deficits in insects and discusses the value of these studies to understand aging processes in all animals.