Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective.

@article{Ruthazer2004InsightsIA,
  title={Insights into activity-dependent map formation from the retinotectal system: a middle-of-the-brain perspective.},
  author={Edward S. Ruthazer and Hollis T. Cline},
  journal={Journal of neurobiology},
  year={2004},
  volume={59 1},
  pages={134-46}
}
The development of orderly topographic maps in the central nervous system (CNS) results from a collaboration of chemoaffinity cues that establish the coarse organization of the projection and activity-dependent mechanisms that fine-tune the map. Using the retinotectal projection as a model system, we describe evidence that biochemical tags and patterned neural activity work in parallel to produce topographically ordered axonal projections. Finally, we review recent experiments in other CNS… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS