Insights into Triterpene Acids in Fermented Mycelia of Edible Fungus Poria cocos by a Comparative Study

  title={Insights into Triterpene Acids in Fermented Mycelia of Edible Fungus Poria cocos by a Comparative Study},
  author={Jian Jin and Rongrong Zhou and J. Xie and Huixuan Ye and Xue-juan Liang and Can Zhong and Bingbing Shen and You Qin and Shui-han Zhang and Luqi Huang},
As an edible sclerotia-forming fungus, Poria cocos is widely used as a food supplement and as a tonic in China. High-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (HPLC-QTOF-MS/MS) was applied to identify triterpene acids in fermented mycelia of P. cocos, as well as the epidermis and inner part of natural sclerotia. A total of 19 triterpene acids were identified in fermented mycelia, whereas 31 were identified in the epidermis and 24 in the inner part. Nine… Expand
5 Citations
Comparative Studies on Polysaccharides, Triterpenoids, and Essential Oil from Fermented Mycelia and Cultivated Sclerotium of a Medicinal and Edible Mushroom, Poria Cocos
The results suggested that it is applicable to produce polysaccharides and triterpenoids by the fermentation of P. cocos, and a strategy to improve triter penoid production in the fermentation process was proposed. Expand
Antioxidant and anti-tumour activity of triterpenoid compounds isolated from Morchella mycelium
The results suggest that triterpenoid compounds from Morchella mycelium fermentation, which are found in functional foods and used in the field of pharmacology, might be excellent products for the treatment of cancer and age-related illnesses. Expand
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The review summarizes the phytochemistry and pharmacological properties of Poria cocos, which suggest that researchers should focus on the development of new drugs about Pia cocos to make them exert greater therapeutic potential. Expand
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The world population is aging, and cancer is always considered to be one of the major causes of death all over the globe. The advent of recent drug-targeted therapies undoubtedly is going to reduceExpand
Poria Cocos Ameliorates Bone Loss in Ovariectomized Mice and Inhibits Osteoclastogenesis In Vitro
The results indicate that PC negatively regulated osteoclast differentiation and function, and can potentially be used to manage postmenopausal osteoporosis. Expand


Accumulation of biomass and four triterpenoids in two-stage cultured Poria cocos mycelia and diuretic activity in rats.
It is suggested that ethanol extract of cultured mycelia showed significant diuretic activity in rats and two-stage culture of P. cocos could be an alternative way to produceMycelia and triterpenoids. Expand
[Dynamic accumulation of three main triterpenic acids in submerged cultivation mycelium of Poria cocos].
  • Y. Zhang, G. Hu, +4 authors Jingming Jia
  • Chemistry, Medicine
  • Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
  • 2013
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Anti-inflammatory activity of the sclerotia of edible fungus, Poria cocos Wolf and their active lanostane triterpenoids
Abstract Poria cocos Wolf confers large, edible sclerotia, known as ‘Indian bread’ in North America. Chemical investigation of EtOH extract of the sclerotia of P. cocos resulted in the identificationExpand
Comparative study of lanostane-type triterpene acids in different parts of Poria cocos (Schw.) Wolf by UHPLC-Fourier transform MS and UHPLC-triple quadruple MS.
This study represents the first reported comprehensive analysis of lanostane-type triterpene acids in FLP and BFL parts of P. cocos, and demonstrated that dehydrotumulosic acid, trametenolic acid, dehydrotrametenolics acid and poricoic acid A were the main compounds contributing to the clusters in FLp and B FL. Expand
Bioactive compounds from sclerotia extract of Poria cocos that control adipocyte and osteoblast differentiation.
Findings demonstrate that the EtOH extract of P. cocos sclerotia is worth consideration as a new potential source of bioactive compounds effective in the treatment of osteoporosis in the elderly, since the extract contains sterols that inhibit adipogenic differentiation as well as diterpenes that promote osteogenic differentiation from MSCs. Expand
Qualitatively and quantitatively comparing secondary metabolites in three medicinal parts derived from Poria cocos (Schw.) Wolf using UHPLC-QTOF-MS/MS-based chemical profiling.
Detailed results showed that the analytes accumulated mostly in the epidermis and inner part, with the least accumulation in the middle part, which provides a factual chemical basis not only for discrimination in therapeutic practice but also for quality evaluation of Poria cocos. Expand
Systematic screening and characterization of the major bioactive components of Poria cocos and their metabolites in rats by LC-ESI-MS(n).
This study proposed a series of potential bioactive components of Poria cocos and provided helpful chemical information for further research on the action mechanism of traditional Chinese medicine. Expand
Simultaneous Identification and Dynamic Analysis of Saccharides during Steam Processing of Rhizomes of Polygonatum cyrtonema by HPLC–QTOF–MS/MS
The high content of fructose was revealed to be the main determinant for increasing the level of sweetness after steaming, and could be considered as markers for the steaming process of rhizomes of P. cyrtonema. Expand
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Besides the identified key factors of pH-shift from 3.0 to 4.5 on day 4 and dissolved oxygen tension (DOT) shift from 25 to 10% on day 6, lower shear stress was also demonstrated to be a key factorExpand
Diuretic activity of some fractions of the epidermis of Poria cocos.
This study confirmed that the ethyl acetate and n-butanol fractions present a remarkable diuretic effect, showing that they are the diUREtic bioactive fractions of Fu-Ling-Pi. Expand