Insights into TREM 2 biology by network analysis of human brain gene expression data

@inproceedings{Forabosco2013InsightsIT,
  title={Insights into TREM 2 biology by network analysis of human brain gene expression data},
  author={Paola Forabosco and Adaikalavan Ramasamy and Daniah Trabzuni and Robert Walker and Colin Smith and Jose T Bras and Adam P Levine and John Hardy and Jennifer M. Pocock and Rita Guerreiro and Michael E. Weale and Mina Ryten},
  year={2013}
}
Rare variants in TREM2 cause susceptibility to late-onset Alzheimer’s disease. Here we use microarraybased expression data generated from 101 neuropathologically normal individuals and covering 10 brain regions, including the hippocampus, to understand TREM2 biology in human brain. Using network analysis, we detect a highly preserved TREM2-containing module in human brain, show that it relates to microglia, and demonstrate that TREM2 is a hub gene in 5 brain regions, including the hippocampus… CONTINUE READING

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