Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer

@inproceedings{Fuziwara2015InsightsIR,
  title={Insights into Regulation of the miR-17-92 Cluster of miRNAs in Cancer},
  author={Cesar Seigi Fuziwara and Edna T. Kimura},
  booktitle={Front. Med.},
  year={2015}
}
Overexpression of the miR-17-92 cluster is a key oncogenic event in various cancer types. The oncogenic effect of the miR-17-92 cluster is enhanced by cooperation between its members in targeting tumor-suppressive proteins and pathways such as PTEN and TGFβ signaling. However, in the case of miR-19a and miR-19b, these have been shown to have a preponderant role in the cluster's oncogenicity. Important studies have revealed the influence of the Myc proto-oncogene family in the transcriptional… CONTINUE READING
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