Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

  title={Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity},
  author={E. Castelli and J. Ramalho and I. O. Porto and T. H. Lima and L. P. Fel{\'i}cio and A. Sabbagh and E. Donadi and C. T. Mendes-Junior},
  journal={Frontiers in Immunology},
  • E. Castelli, J. Ramalho, +5 authors C. T. Mendes-Junior
  • Published 2014
  • Biology, Medicine
  • Frontiers in Immunology
  • Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function of class I non-classical genes. The main features that distinguish HLA-G from classical class I genes are (a) limited protein variability, (b) alternative splicing generating several membrane bound and soluble isoforms, (c) short cytoplasmic tail, (d) modulation of immune… CONTINUE READING
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    Publications referenced by this paper.
    HLA-G polymorphisms in African Americans.
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    Evidence of balancing selection at the HLA-G promoter region.
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    • Highly Influential
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