Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity

  title={Insights into HLA-G Genetics Provided by Worldwide Haplotype Diversity},
  author={Erick C Castelli and Jaqueline Ramalho and Iane O. P. Porto and Th{\'a}litta Hetamaro Ayala Lima and Leandro Prado Fel{\'i}cio and Audrey Sabbagh and Eduardo Ant{\^o}nio Donadi and Celso Teixeira Mendes-Junior},
  booktitle={Front. Immunol.},
Human leukocyte antigen G (HLA-G) belongs to the family of non-classical HLA class I genes, located within the major histocompatibility complex (MHC). HLA-G has been the target of most recent research regarding the function of class I non-classical genes. The main features that distinguish HLA-G from classical class I genes are (a) limited protein variability, (b) alternative splicing generating several membrane bound and soluble isoforms, (c) short cytoplasmic tail, (d) modulation of immune… CONTINUE READING


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