Insights into Factorless Translational Initiation by the tRNA-Like Pseudoknot Domain of a Viral IRES

@inproceedings{Au2012InsightsIF,
  title={Insights into Factorless Translational Initiation by the tRNA-Like Pseudoknot Domain of a Viral IRES},
  author={Hilda H T Au and Eric Jan},
  booktitle={PloS one},
  year={2012}
}
The intergenic region internal ribosome entry site (IGR IRES) of the Dicistroviridae family adopts an overlapping triple pseudoknot structure to directly recruit the 80S ribosome in the absence of initiation factors. The pseudoknot I (PKI) domain of the IRES mimics a tRNA-like codon:anticodon interaction in the ribosomal P site to direct translation initiation from a non-AUG initiation codon in the A site. In this study, we have performed a comprehensive mutational analysis of this region to… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Crystal structures of complexes containing domains from two viral internal ribosome entry site (IRES) RNAs bound to the 70S ribosome.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2011
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Alternative reading frame selection mediated by a tRNA-like domain of an internal ribosome entry site.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 2 EXCERPTS

Crystal

KE Berry, S Waghray, SA Mortimer, Y Bai, JA Doudna
  • structure
  • 2011