Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus.

@article{Savino2004InsightsID,
  title={Insights into DNA replication: the crystal structure of DNA polymerase B1 from the archaeon Sulfolobus solfataricus.},
  author={C. Savino and L. Federici and Kenneth A. Johnson and B. Vallone and V. Nastopoulos and M. Rossi and F. Pisani and D. Tsernoglou},
  journal={Structure},
  year={2004},
  volume={12 11},
  pages={
          2001-8
        }
}
To minimize the large number of mispairs during genome duplication owing to the large amount of DNA to be synthesized, many replicative polymerases have accessory domains with complementary functions. We describe the crystal structure of replicative DNA polymerase B1 from the archaeon Sulfolobus solfataricus. Comparison between other known structures indicates that although the protein is folded into the typical N-terminal, editing 3'-5'exonuclease, and C-terminal right-handed polymerase… Expand
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